3-Ketoacyl-CoA

3-Ketoacyl-CoA is an intermediate in the oxidation of fatty acids. It is the last acyl moiety made prior to cleavage of the acetyl group by thiolase. 3-Ketoacyl-CoA is produced and used (respectively) in the reactions that follow (Figure 18.16):

> 1. L-3-Hydroxyacyl-S-CoA + NAD+ <=> 3-Ketoacyl-S-CoA + NADH + H+ (catalyzed by 3-Hydroxyacyl-CoA Dehydrogenase)

> 2. 3-Ketoacyl-CoA + CoASH <=> Acyl-CoA (less 2 carbons) + Acetyl-CoA (catalyzed by Thiolase).

See also: Oxidation of Saturated Fatty Acids, Unsaturated Fatty Acid Oxidation, Oxidation of Odd-Numbered Fatty Acids, Peroxisomal -Oxidation, Fatty Acids

INTERNET LINK: Fatty Acid Metabolism