Phosphatidylglycerol-3-Phosphate

Phosphatidylglycerol-3-phosphate is an intermediate in synthesis of cardiolipin. It is made by addition of glycerol-3-phosphate to CDP-diacylglycerol (Figure 19.4) in the reaction that follows.

CDP-Diacylglycerol + Glycerol-3-Phosphate (or Myoinositol or Serine) <=> Phosphatidylglycerol-3-Phosphate (or Phosphatidylinositol or Phosphatidylserine) + CMP

Subsequently, the external phosphate is hydrolyzed to make phosphatidylglycerol, which is then joined with another phosphatidylglycerol to make cardiolipin (Figure 19.4).

See also: Glycerophospholipid Pathway, Glycerophospholipid Biosynthesis in Bacteria, Glycerophospholipids, Glycerophospholipid Pathway,

INTERNET LINKS

> 1. Glycerolipid Metabolism

> 2. Phospholipid Catabolism