Ganciclovir

Ganciclovir is an antiviral drug used to treat herpesvirus infection. The basis of its action is that ganciclovir resembles part of the guanosine nucleoside and is phosphorylated by the viral enzyme, deoxypyrimidine kinase. The phosphorylated triphosphate form of ganciclovir is an inhibitor of the herpesvirus DNA polymerase. A related compound, acyciclovir, works similarly. Uninfected cells do not efficiently phosphorylate ganciclovir and acyclovir, so DNA replication and virus growth are inhibited selectively in infected cells.

See also: Nucleotide Analogs in Medicine, Nucleotide Salvage Synthesis, Salvage Routes to Deoxyribonucleotide Synthesis