Dihydrofolate Reductase

Dihydrofolate Reductase - Figure 22.18 illustrates the important role of dihydrofolate reductase in the pathways regenerating tetrahydrofolate from the dihydrofolate generated in the synthesis of dTMP from dUMP. Inhibitors of dihydrofolate reductase, such as methotrexate and trimethoprim, ultimately inhibit production of dTTP.

See also: De Novo Biosynthesis of Purine Nucleotides, Tetrahydrofolate Coenzymes, DHF, THF, 5,10-Methylene THF, Nucleotide Analogs in Medicine, Gene Amplification

INTERNET LINK:

> 1. DHFR, The Movie

> 2. One Carbon Pool by Folate