Malonyl-ACP

Malonyl-ACP is an intermediate in fatty acid biosynthesis. It is produced in the reaction below (Figure 18.24):

> Malonyl-CoA + ACP <=> Malonyl-ACP + CoASH (catalyzed by Malonyl-CoA-ACP Transacylase)

Malonyl-ACP subsequently donates an acetyl group to growing fatty acid chain in reaction that follows:

> Acetyl-ACP + Malonyl-ACP <=> -Ketoacyl-ACP + ACP + CO 2 (catalyzed by -Ketoacyl-ACP Synthase)

See also: Fatty Acid Biosynthesis Strategy, Fatty Acid Synthase, Fatty Acids, Palmitate Synthesis from Acetyl-CoA, Synthesis of Long Chain Fatty Acids, Figure 18.27

INTERNET LINK: Fatty Acid Biosynthesis