2,4-Dienoyl-CoA Reductase

2,4-dienoyl-CoA reductase is an enzyme essential for oxidation of unsaturated fatty acids. It catalyzes the formation of cis-3-enoyl-CoA from trans-2-cis-4-enoyl-CoA (Reaction #5, Figure 18.18).

Along with the enzyme enoyl-CoA isomerase, 2,4-dienoyl-CoA reductase permits unsaturated fatty acids in the diet containing cis double bonds to be catabolized.

See also: Enoyl-CoA Isomerase, Oxidation of Unsaturated Fatty Acids, Oxidation of Fatty Acids