IMP Dehydrogenase

IMP dehydrogenase catalyzes the reaction that follows:

> Inosine Monophosphate (IMP) + NAD+ + H 2O <=> Xanthosine Monophosphate (XMP) + NADH + H+

The reaction is part of the de novo biosynthetic pathway of purines. IMP dehydrogenase is allosterically inhibited by GMP, the end product of the pathway.

See also: Figure 22.6, De Novo Biosynthesis of Purine Nucleotides

INTERNET LINKS:

> 1. Purine Metabolism

> 2. Purine and Pyrimidine Metabolism