L-Homoserine

L-Homoserine is found in many tissues as a intermediate in amino acid metabolism, including threonine, isoleucine, and methionine. Catabolism of aspartate to homoserine is shown here. The biosynthetic pathway from homoserine to methionine is shown in Figure 21.6.

> Aspartic Semialdehyde + NADPH + H+ <=> Homoserine + NADP+ (catalyzed by homoserine dehydrogenase).

See also: Amino Acids Not In Proteins, Metabolism of Serine, Glycine, and Threonine, Metabolism of Valine, Leucine, Isoleucine, and Lysine, Metabolism of Sulfur-Containing Amino Acids

INTERNET LINK: Gly, Ser, Thr Metabolism