-Keto-Thiolase (Thiolase)

Thiolase is an enzyme of the fatty acid oxidation cycle that adds a CoASH to -keto-acyl-CoA to convert it to an acyl-CoA with two less carbons plus acetyl-CoA:

> 3-Ketoacyl-CoA + CoASH <=> Acyl-CoA (less 2 carbons) + Acetyl-CoA

Thiolase is also important in formation of ketone bodies when the acetyl-CoA concentration is high.

See also: Oxidation of Saturated Fatty Acids, Unsaturated Fatty Acid Oxidation, Oxidation of Odd-Numbered Fatty Acids, Peroxisomal -Oxidation, Fatty Acids, Ketogenesis

INTERNET LINK: Fatty Acid Metabolism