Succinyl-CoA Synthetase

Succinyl-CoA synthetase (also called succinate thiokinase) is an enzyme of the citric acid cycle that catalyzes the reaction below:

> Succinyl-CoA + Pi + GDP <=> Succinate + GTP + CoASH ( = -2.9 kJ/mol)

Note that the enzyme is named for the reverse reaction. Plants and bacteria form ATP from ADP instead of using GDP/GTP. GTP and ATP can be interconverted in the reaction catalyzed by NDPK:

Next enzyme of citric acid cycle / Previous enzyme of citric acid cycle

See also: Citric Acid Cycle Enzymes, Figure 14.3, Table 14.1, Substrate Level Phosphorylation

INTERNET LINK: Citric Acid Cycle