Pyruvate Kinase Regulation

The glycolytic enzyme, pyruvate kinase, is regulated by several mechanisms:

> 1. Liver pyruvate kinase is inhibited by high ATP.

> 2. Pyruvate kinase is activated by F1,6BP

> 3. Carbohydrate ingestion stimulates the enzyme

> 4. The liver pyruvate kinase is regulated by phosphorylation (less active) / dephosphorylation (more active). This is under hormonal control.

> 5. Glucagon represses synthesis of pyruvate kinase.

See also: Pyruvate Kinase Isozymes, F1,6BP, Glucagon