17-Hydroxyprogesterone

17-Hydroxyprogesterone is a branch point between synthesis of the glucocorticoids and the androgens. Thus, deficiency of 17-hydroxylase, the enzyme responsible for catalyzing the synthesis of 17-hydroxyprogesterone, leads to reduced amounts of corstisol (glucocorticoid), androgens, and estrogens.

See also: Steroid Hormone Synthesis, Steroid Metabolism, Steroid Hormones, Cholesterol Biosynthesis, Cholesterol

INTERNET LINKS:

> 1. Steroid Hormone Metabolism

> 2. Androgen and Estrogen Metabolism

> 3. Aromatase Reaction Mechanism