Foam Cells

Oxidative damage to LDLs in the bloodstream stimulates production of a class of white blood cells that bind to the damaged LDL and absorb them in a process similar, but not identical to receptor mediated endocytosis. Since LDLs contain a good deal of chlolesterol and cholesterol uptake by these cells is virtually unlimited, the cells become filled with cholesterol. These cholesterol-engorged immune cells are referred to as "foam cells".

See also: Receptor Mediated Endocytosis, Atherogenesis, LDL, Cholesterol, Scavenger Receptor