Nucleoside Diphosphokinase (NDPK)

NDPK is an enzyme that catalyzes the reaction that follows:

> NDP + ATP <=> NTP + ADP,

where NDP is a nucleoside diphosphate (ADP, GDP, CDP, or UDP) and NTP is a nucleoside triphosphate (ATP, GTP, CTP, or UTP). The enzyme will also use dNDPs as its substrates, as follows,

> dNDP + ATP <=> dNTP + ADP,

where dNDP is a deoxynucleoside diphosphate (dADP, dCDP, dUDP, dGDP, or dTDP) and dNTP is a deoxynucleoside triphosphate (dATP, dCTP, dUTP, dGTP, or dTTP).

NDPK uses energy of ATP to make triphosphates of ribonucleoside diphosphates and deoxyribonucleoside diphosphates in both de novo and salvage biosynthesis.

See also: De Novo Biosynthesis of Purine Nucleotides, De Novo Pyrimidine Nucleotide Metabolism, Nucleotide Salvage Synthesis, Salvage Routes to Deoxyribonucleotide Synthesis