Coenzyme A (CoA or CoASH)

Coenzyme A participates in the activation of acyl groups, including the acetyl group derived from pyruvate (see here ). Coenzyme A is composed of parts from ATP, pantothenic acid, and -mercaptoethylamine. The thiol (-SH) on the -mercaptoethylamine moiety is the site where the acyl groups are covalently linked via a high energy thioester bond.

See also: Thioester Bond Energy