Mevalonic Acid (Mevalonate)

Mevalonate is an intermediate in isoprenoid biosynthesis. It is product of the reaction catalyzed by HMG-CoA reductase, as follows:

> HMG-CoA + 2 NADPH + H+ <=> Mevalonate + CoASH + 2 NADP+ (Figure 19.18)

Subsequently, mevalonate is converted to 5-phosphomevalonate, as shown in Figure 19.19.

See also: Steroid Metabolism, Cholesterol Biosynthesis

INTERNET LINKS:

> 1. Terpenoid Biosynthesis

> 2. Sterol Biosynthesis