Adenylate Cyclase

Adenylate cyclase is a membrane-bound enzyme that, after stimulation by a G protein, catalyzes formation of cAMP from ATP (see below). cAMP, thus formed, stimulates activation of a kinase cascade that affects several metabolic pathways, such as glycogen metabolism (see here) and gluconeogenesis. Adenylate cyclase plays an important role in signal transduction.

> ATP <=> cAMP + PPi

See also: Figure 13.18, Figure 16.11, Action of Epinephrine, G Protein Families and Subunits, G Proteins and Signal Transduction