Outline

Introduction (Figure 6.1)

Secondary Structure: Regular Ways to Fold the Polypeptide Chain

> Discovery of Regular Polypeptide Structures (Figure 5.12b, Figure 6.2, Figure 6.3, Figure 6.4)

> Describing the Structures: Molecular Helices and Pleated Sheets (Figure 6.5, Figure 6.6, Table 6.1)

> Ramachandran Plots (Figure 6.2, Figure 6.8, Figure 6.9, Figure 6.10)

Fibrous Proteins: Structural Materials of Cells and Tissues (Table 6.2)

> The Keratins (Figure 6.11)

> Fibroin (Figure 6.12, Table 6.2)

> Collagen

> > Collagen Structure (Figure 6.13, Figure p. 179)
> > Collagen Synthesis (Figure 6.14)

> Elastin (Unnumbered Figure)

Globular Proteins: Tertiary Structure and Functional Diversity

> Different Folding for Different Functions (Figure 6.1, Figure 6.16)

> Varieties of Globular Protein Structure: Patterns of Folding (Figure 6.16, Figure 6.17, Figure 6.18, Figure 6.19)

Factors Determining Secondary and Tertiary Structure

> The Information for Protein Folding (Figure 6.20)

> The Thermodynamics of Folding

> > Conformational Entropy
> > Charge-Charge Interactions
> > Internal Hydrogen Bonds (Figure 6.21)
> > van der Waals Interactions (Table 6.3)
> > The Hydrophobic Effect (Table 6.4, Figure 6.22)

> The Role of Disulfide Bonds (Figure 6.23)

Dynamics of Globular Protein Structure

> Kinetics of Protein Folding (Figure 6.24)

> Kinetics of Disulfide Bond Formation (Figure 6.25)

> Chaperonins (Figure 6.26)

> Motions Within Globular Protein Molecules (Table 6.5)

> Prions - Protein Folding and Mad Cow Disease (Figure 6.27)

Prediction of Secondary and Tertiary Protein Structure

> Prediction of Secondary Structure (Table 6.6, Figure 6.28)

> Tertiary Structure: Computer Simulation of Folding

Quaternary Structure of Proteins (Figure 6.29)

> Multisubunit Proteins: Homotypic Protein-Protein Interactions (Figure 6.30, Figure 6.32, Figure 6.33)

> Heterotypic Protein-Protein Interactions